Adverse effects of Methotrexate in Psoriasis

What is Methotrexate ?

Methotrexate is a conventional medicine used for diseases such as cancer, autoimmune diseases, Psoriasis, Ankylosing Spondylitis, rheumatoid arthritis, Crohn's disease, etc. It is administered either oral or by injection. Usually, it is supposed to be administered after failure with milder medicines.

What are the adverse effects of Methotrexate ?

Methotrexate produces a range of adverse effects in different patents. Some of the adverse effects can be extremely severe and even life-threatening.

The adverse effects could be listed here :

Mouth :
inflamed stomach, ulcers in mouth, loss of appetite, nausea, vomiting, diarrhea, bleeding from stomach and intestines
Blood, bone-marrow and lymphatic system :
Anemia, low white cells, low platelets cells
Heart and cardiovascular system :
low blood pressure, cerebral thrombosis, deep vein thrombosis.
Brain and CNS :
Vertigo,Headaches, drowsiness, speech disorder
Infections :
Use of Methotrexate may make one prone to certain infections such as  pneumonia, sepsis, nocardiosis; histoplasmosis, cryptococcosis, Herpes zoster, Herpes  simplex, hepatitis, etc.
Lungs :
Pulmonary fibrosis, lung failure, pneumonitis
Skin :
Erythematous skin rashes, itching, urticaria, photosensitivity, pigmentary changes, alopecia, ecchymosis, telangiectasia, acne, furunculosis, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, skin necrosis, skin ulceration, and exfoliative dermatitis.
Kidney :
Kidney failure, inflamed bladder, bleeding from urinary tract, defective sperm formation
Hormonal :
Menstrual dysfunction, vaginal discharge, enlargement of breast in males, infertility, abortion.

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