Adverse effects of Cyclophosphamide in Psoriasis

Cyclophosphamide is a powerful drug which can stop the process of cell division irrespective of which phase of cell division is in progress.

Digestive system :

  • Nausea and vomiting.
  • Pain in abdomen accompanied by diarrhea.
  • Constipation.
  • Ulcers in the oral cavity as well as in the large intestine.
  • Bloody diarrhea with jaundice.

Urinary system :

  • Inflammation of the urinary bladder.
  • Inflammation of the urethra causing blood in urine.

Vision :

  • Blurred vision with headache and dizziness

Skin :

  • Wide spread skin rashes.
  • Nails and skin show pigmentation.
  • Jaundice (yellow discoloration of the skin).
  • Moderate to severe forms of hair loss.

Blood and circulatory system :

  • Reduced production of neutrophils (a form of white blood cells which fight against infections). This can result in frequent fevers and infections.
  • Decrease in the actual number of white blood cells (leucopenia)

Respiratory system :

  • Inflammation of the lung tissues that ultimately result in fibrosis.

Some of the more serious adverse effects of this drug are as follows: :

  • This drug is not suggested to pregnant women
  • There are incidences where it has resulted in infertility in both men and women.
  • Even in non-regnant women,this drug disturb menstrual cycles
  • Cancers of the kidney have been reported in some of cases.
  • Inflammation of the urinary bladder and urethra causing bloody urine which can lead to serious blood loss.
  • Inflammation of the blood vessels supplying the brain has been reported.
  • Cyclophosphamide can lead to inflammation of the heart muscles which can eventually lead to congestive heart failure.

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