Adverse effects of Cyclophosphamide in Psoriasis

Cyclophosphamide is a powerful drug which can stop the process of cell division irrespective of which phase of cell division is in progress.

• Nausea and vomiting.
• Pain in abdomen accompanied by diarrhea.
• Constipation.
• Ulcers in the oral cavity as well as in the large intestine.
• Bloody diarrhea with jaundice.

• Inflammation of the urinary bladder.
• Inflammation of the urethra causing blood in urine.

• Blurred vision with headache and dizziness

• Wide spread skin rashes.
• Nails and skin show pigmentation.
• Jaundice (yellow discoloration of the skin).
• Moderate to severe forms of hair loss.

• Reduced production of neutrophils (a form of white blood cells which fight against infections). This can result in frequent fevers and infections.
• Decrease in the actual number of white blood cells (leucopenia)

• Inflammation of the lung tissues that ultimately result in fibrosis.

• This drug is not suggested to pregnant women
• There are incidences where it has resulted in infertility in both men and women.
• Even in non-regnant women,this drug disturb menstrual cycles
• Cancers of the kidney have been reported in some of cases.
• Inflammation of the urinary bladder and urethra causing bloody urine which can lead to serious blood loss.
• Inflammation of the blood vessels supplying the brain has been reported.
• Cyclophosphamide can lead to inflammation of the heart muscles which can eventually lead to congestive heart failure.

Some Important Links you want to Visit :

• Adverse effect of steroids in Psoriasis
• Adverse effect of methotraxate in Psoriasis
• Adverse effect of cyclosporine in Psoriasis